Gastrointestinal

Zollinger-Ellison Syndrome

Zollinger-Ellison syndrome is a condition in which gastrin-secreting tumors (gastrinomas) cause excessive stomach acid production and severe recurrent peptic ulcers.

5

Symptoms

3

Causes

4

Treatments

3

Prevention

Condition Overview

Understand key symptoms, causes, diagnosis options, and treatment pathways for Zollinger-Ellison Syndrome. This overview is intended for patient awareness and should be followed by specialist consultation.

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Symptoms

  • Abdominal pain
  • Recurrent peptic ulcers
  • Chronic diarrhea
  • Acid reflux and heartburn
  • Nausea or gastrointestinal bleeding in severe cases

Causes

  • Gastrinoma tumors in pancreas or duodenum
  • Excess gastrin secretion
  • Association with MEN1 syndrome in some patients

Diagnosis

  • Fasting serum gastrin levels
  • Gastric acid secretion studies
  • Secretin stimulation test
  • Imaging for tumor localization

Treatment

  • High-dose proton pump inhibitors
  • Surgical removal when feasible
  • Management of metastatic disease when present
  • Long-term GI and oncology follow-up

Risk Factors

  • MEN1 genetic syndrome
  • Family history of endocrine tumors

Prevention

  • No specific primary prevention
  • Early screening in high-risk MEN1 families
  • Prompt treatment to prevent ulcer complications

Prevalence

Rare endocrine-gastrointestinal disorder.

Related Conditions

Gastrointestinal

Zenkers Diverticulum

Zenker’s diverticulum is an outpouching of the upper esophagus that can cause swallowing problems and regurgitation, typically in older adults.

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