Bone Disease

Osteoporosis

Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. As a result, bones become weak and may break from a fall or, in serious cases, from minor bumps or even from sneezing. Osteoporosis means 'porous bone.' It is the most common reason for a broken bone among older adults.

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Symptoms

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Causes

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Treatments

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Prevention

Condition Overview

Understand key symptoms, causes, diagnosis options, and treatment pathways for Osteoporosis. This overview is intended for patient awareness and should be followed by specialist consultation.

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Symptoms

  • No symptoms in early stages
  • Back pain (due to fractured or collapsed vertebra)
  • Loss of height over time
  • Stooped posture
  • Bone fracture more easily than expected

Causes

  • Bone density peaks around age 30 then declines
  • Hormonal changes (menopause, low testosterone)
  • Calcium and vitamin D deficiency
  • Sedentary lifestyle
  • Certain medications (steroids, some cancer treatments)

Diagnosis

  • DEXA scan (bone mineral density)
  • Blood and urine tests
  • X-rays
  • Vertebral fracture assessment
  • FRAX fracture risk tool

Treatment

  • Calcium and vitamin D supplements
  • Bisphosphonates
  • RANK ligand inhibitors (denosumab)
  • Hormone therapy
  • Bone-building medications (teriparatide)
  • Exercise

Risk Factors

  • Female sex
  • Advanced age
  • Low body weight
  • Family history
  • Low sex hormone levels
  • Smoking
  • Excessive alcohol use
  • Certain medications

Prevention

  • Adequate calcium and vitamin D intake
  • Regular weight-bearing exercise
  • Avoid smoking
  • Limit alcohol
  • Fall prevention

Prevalence

About 10 million Americans have osteoporosis; another 44 million have low bone density.